Announcing OMF's First ME/CFS Clinical Trial!

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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada

Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Long COVID.

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Kynurenine Clinical Trial for ME / CFS

Open Medicine Foundation is excited to announce its support of an initiation of a clinical trial to understand potential disturbances in the tryptophan metabolism and to test the benefits of treating people with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) with Kynurenine. Kynurenine is naturally produced in the body, is a key metabolite in the tryptophan metabolism, […]

A message from Linda Tannenbaum regarding COVID-19

I know this is an especially stressful and uncertain time for patients and their families due to the coronavirus, and I am sending you all my strength and support. I have seen so many examples over the years of how resilient and compassionate this community is, and I trust we will come through this newest challenge […]

Stanford Working Group

Ronald W. Davis, PhD* Alain Moreau, PhD* Alan Light, PhD Alex Arron Kashi, BS Ami Mac, MD Amit Kumar Saha, PhD Amrit Shahzad, PhD Anand Ramasubramanian, PhD Anna Okumu Arun Kumar Baldomero Olivera, PhD Bela Chheda, MD Ben Wendel, PhD Brendan Robert Schmidt Bruce Schaar, PhD Christopher Armstrong, PhD* Christopher Gregg, PhD Craig Heller, PhD […]

About Ronald W. Davis, PhD

Throughout his career, Dr. Davis has conducted cutting edge, innovative, interdisciplinary research and technology development on cancer, immunology, genetics, infectious disease, novel drug development, and nanofabrication of diagnostic instruments. His emphasis has always been to increase accuracy and decrease cost. He has made significant contributions to research on numerous organisms, including bacteria, yeast, plants and […]

Stanford Research Update from Ronald W. Davis, PhD.

A Message To You From Ronald W. Davis, PhD Dr. Ron Davis, OMF Scientific Advisory Board Director and Director of the OMFCA-funded ME/CFS Collaborative Research Center at Stanford University, has a message of hope for the entire ME/CFS community. Dr. Davis and his team at Stanford are continuing to expand research and leave no stone […]

OMFCA Funded ME/CFS Collaborative Research Centre at Stanford

An End of Year Message from Ronald W. Davis, PhD, and Janet Dafoe, PhD We have accomplished so much with the amazing donations generously given to OMF and OMFCA and we are grateful. We have collected huge amounts of data in our Severely Ill Patients Study, which has yielded lots of information and hypotheses. We […]

#TripleTuesdayOMFCA Spotlight – iCPET Study

Proteomic and Metabolic Plasma iCPET Studies By Ronald G.Tompkins, MD, ScD We have received an anonymous grant of $350,000 designated for the “Proteomic and Metabolomic Plasma iCPET Studies” within the OMFCA-funded Harvard ME / CFS Collaboration at the Harvard-Affiliated Hospitals. Dr. David Systrom and his colleagues at the Brigham and Women’s Hospital have developed a […]

Experts advance ME/CFS research: Chris Armstrong interviewed on ME/CFS Alert

Dr. Christopher Armstrong Talks with Llewellyn King Llewellyn King, host of ME/CFS Alert, has just released his newest episode interviewing OMF Science Liaison Christopher Armstrong, PhD. This edition covers Dr. Armstrong’s pathway into ME/CFS research, his areas of expertise, and his role to help advance OMFCA’s ME/CFS research. This is the third in a series […]

ME/CFS Research is soaring!

#TripleTuesdayOMFCA Spotlight – Chris Armstrong, PhD Every donation today through December 3 will be tripled!   I’m getting in touch with you today to share my personal perspective on why your support is so vital to OMF Canada’s (OMFCA) work. Donations from community members like you allow OMFCA to fund critical research around the globe […]

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.