STUDY HYPOTHESIS AND DESCRIPTION
STUDY HYPOTHESIS AND DESCRIPTION
A condensed personalized research protocol would be the minimum number of samples from specific conditions that can accurately develop a biological signature unique to an individual with ME/CFS that can be used predict the improvement or worsening of their symptoms.
This protocol would be useful for tracking the development of ME/CFS, provide an understanding of the biology of the disease process in the individual, stratify ME/CFS individuals into biologically-defined subsets, test the efficacy of treatments, and monitor outcomes in clinical treatment trials.
OBJECTIVES

- Establish a condensed personalized research protocol that can be used to characterize ME/CFS in individual patients as it pertains their biological aspects of their self and a complex chronic disease.
- Integrate and analyze the data from metabolic longitudinal studies.
- Randomly sample each participants longitudinal data and analyze if a similar pattern can be observed with less data points.
- Develop an algorithm to recognize individual signatures and compare them across patients to identify patterns that can then reduce the length of the personalized research method.
- Test and validate algorithm on combined datasets bootstrapping.
- Retest tool by retesting a number of ME/CFS patients to determine if signature produced is consistent with the past.