Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Post COVID .

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Developing condensed precision research protocol for ME/CFS

PROTOCOL AIM
Establish a condensed personalized research protocol that can be used to characterize ME/CFS in individual patients as it pertains to all their unique biological aspects of their self, interacting with a complex chronic disease.
LEAD INVESTIGATORS
  • Christopher Armstrong, PhD
  • Paul Gooley, PhD
  • Neil McGregor, PhD
  • David Ascher, PhD
PROTOCOL VALUE

This protocol would be useful for tracking the development of ME/CFS, provide an understanding of the biology of the disease process in the individual, stratify ME/CFS individuals into biologically-defined subsets, test the efficacy of treatments, and monitor outcomes in clinical treatment trials. 

PROTOCOL DESCRIPTION

A condensed personalized research protocol would be the minimum number of samples from specific conditions that can accurately develop a biological signature unique to an individual with ME/CFS that can be used predict the improvement or worsening of their symptoms.

PROTOCOL DEVELOPMENT

Initially, the biology of 100 people with ME/CFS will be characterized by continuously monitoring their health data and sporadically sampling and analyzing their blood and urine over the course of a year.

Metabolite and Symptom Data will be analyzed to identify signatures of disease severity in individuals that predict increased and decreased disease severity.

Pattern-recognition software will be developed specifically to recognize these signatures and compare them across patients to identify patterns that can then reduce the complexity and length of the personalized research method.