Announcing OMF's First ME/CFS Clinical Trial!

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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada

Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Long COVID.

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LAST DAY this year to TRIPLE your impact toward treatment trials!

Dear Friends,

Thanks to the generosity of our supporters worldwide, I am deeply honored to share that we have surpassed our original fundraising goal for Triple Giving Tuesday — so our leadership donors have stepped up, bringing our new goal to $1,500,000. Today, November 29, is your LAST day to have your contribution TRIPLED!

Help us exceed the new Triple Giving Tuesday goal and please donate today before time runs out! 

Earlier this month, we shared the heartbreaking story of Josiah and Thomas, two brothers with ME/CFS, and Aedan, who is sick with Long COVID. All once active and healthy, their childhoods have been forcibly paused by multi-system chronic, complex diseases (msCCD). Now, they are waiting in the darkness of their bedrooms for answers when they should be out playing with friends. Sadly, these stories are shared by countless families across the world. 


As a mother of a child with ME/CFS, I know this is a pain that no parent or caregiver should experience. In 2006, our world changed forever. Our 16-year-old daughter was so severely ill she could not get out of bed. Overnight she went from being a healthy teenage girl to no longer having the energy to do the most basic of tasks. My husband and I took her to see 20 doctors only to find there were no answers. 

She eventually got a diagnosis of ME/CFS, and we were told that there are no recommended treatment options. Not one. As parents, we are most worried for our children. They deserve care and attention, and when they are sick, all we want to do is make them better. This was the reason that I started Open Medicine Foundation (OMF).

Fast forward to 2022, OMF has marked its 10-year anniversary. This is a huge milestone for OMF. A decade of research progress has now allowed us to move forward with a new arm of research: small clinical treatment trials. Small treatment trials on existing and new drugs waiting to be released are the best way to expedite the discovery of effective, affordable, and accessible treatments. 

 In the last hours of #TripleGivingTuesday, please consider giving today to TRIPLE your impact on small, OMF supported clinical treatment trials. 

Your gift of any amount adds up and makes a real difference as we work towards our mission of ending ME/CFS and msCCD together.

And lastly – I most sincerely thank all who participate in our research projects and to all who donate, fundraise, and help spread the word about our urgent work. Your continued support fills us with gratitude, your resilience inspires us, and your generous donations make our research possible. 

I am grateful beyond words for your continued friendship and support.

With HOPE for all,

 

 

Linda Tannenbaum 
OMF Founder & CEO/President 

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.