research Archives - Open Medicine Foundation Canada

Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Post COVID .

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NMR Metabolomics

NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.

Proteomics

The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.

Microvesicles and viral sequencing

Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.

Micro RNA

Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.

Autoantibodies

Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.

Extracellular DNA for viral reactivation and Mitochondrial DNA

exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.

Immune cell profiling

The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”

Leukocyte Genomics

A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.

Metabolomics

Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.

Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Post COVID .

OMF Funded Research Centers

Current research Studies

Collaborative Center at Montréal

Collaborative Center at Stanford

The Ronald G. Tompkins Harvard ME / CFS Collaboration

Collaborative Center at Uppsala

Melbourne ME/CFS Collaboration

Computational Research Centerfor Complex Diseases

What Is ME / CFS?

What is Fibromyalgia?

What Is Post-Treatment Lyme Disease Syndrome?

What is Long COVID?

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