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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada
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Coming soon: Triple Giving November and exclusive research updates

OMF Canada Triple Giving November logo

This November, something special is returning — Triple Giving November (TGN)! Thanks to generous matching donors, every dollar you give to Open Medicine Foundation Canada (OMFCA) will be TRIPLED, up to $500,000.

To make sure more people can take part in this opportunity, we’re extending Triple Giving November through December 2 — Giving Tuesday. That means from November 1 to December 2, 2025, your gift will go three times as far in advancing ME/CFS and Long COVID research.

Open Medicine Foundation’s Research Portfolio

OMF’s mission is to drive and fund global collaborative research that unlocks disease biology, delivers precise diagnostics, and advances treatments—giving every patient a pathway to care and hope. To that end, our research portfolio largely consists of three pillars: understanding clear disease mechanisms, enabling accurate diagnosis, and finding effective treatments.

The image shows three rounded rectangular boxes arranged in a row. The first dark blue box reads “Clear disease models from understood mechanisms,” the middle teal box reads “Accurate diagnosis,” and the third dark blue box reads “Effective treatments.”
  • Clear disease models from understood mechanisms: OMF’s investigations into mechanisms of ME/CFS and Long COVID range from looking at the disease as a whole to mechanisms of individual symptoms of the disease. These results help give us insight into potential treatments, either disease-modifying or for symptom management.
  • Accurate diagnosis: OMF aims to identify new tools or clinical tests that can be used to objectively differentiate ME/CFS and Long COVID, including various potential subtypes, from diseases with similar clinical presentation.
  • Effective treatments: OMF is pursuing effective treatments for ME/CFS and Long COVID from multiple angles, including those that contribute to personalized medicine and disease-modifying treatments.

What to expect during TGN

This year, during OMFCA’s TGN we will be sharing a series of interviews with OMF’s Directors, each focusing on the bigger picture and drawing connections between research findings. Keep an eye out for an exciting set of videos spread over four weeks of TGN:

  • Nov 11: Ron Davis, PhD and David Systrom, MD
  • Nov 18: Jonas Bergquist, MD, PhD and Alain Moreau, PhD
  • Nov 25: Chris Armstrong, PhD and Wenzhong Xiao, PhD
  • Dec 2: Panel discussion with all of OMF’s Directors


We’ll be sending an email on November 1 with ways you can support OMFCA during TGN—our most impactful fundraising event of the year. Together, we can triple the progress toward understanding, diagnosing, and treating ME/CFS and Long COVID.

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.