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Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Post COVID .

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Special Request! Join OMFCA’s Hope Builders Community

Introducing April: An artist, person with ME/CFS, & OMF Hope Builder.

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Out Now! Itaconate Shunt Hypothesis Part 2 – Video Interview with Robert Phair & Janet Dafoe

Discover the latest advancements in ME/CFS research with the second installment of the Itaconate Shunt Hypothesis video, with Robert Phair PhD and Janet Dafoe, PhD

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Looking Back and Looking Forward: OMFCA’s 2022 Year in Review

Highlights and progress: OMFCA’s 2022 Year in Review

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LAST DAY in 2022 to donate!

Only a few hours left in 2022 to help OMF fund small treatment trials!

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ONE DAY left to make your 2022 donation!

Only ONE more day to make your 2022 donation to OMF and help fund small treatment trials.

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LAST DAY this year to TRIPLE your impact toward treatment trials!

Support small ME/CFS treatment trials: Nov. 29, 2022 is the LAST DAY this year to get your donation to OMF TRIPLED!

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“How my love for Star Wars led to research into the disease that ruined my life.”

How does OMF research give hope? In a viral Redditt post, an ME/CFS patient known to OMF shares the unique story of how their love of Star Wars inspired hope and led to OMF-supported research.

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Ron Davis: New Neutrophil Study!

A new study from Ron Davis and Stanford colleagues aims to identify neutrophil abnormalities that are unique to ME/CFS patients.

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Our Community Comes Together This Giving November

OMF highlights stories of those who raise awareness and further our mission to end ME/CFS, Long COVID, and related diseases

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NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.