Today, we’re sharing an update on important developments in ME/CFS research — work that is steadily improving our understanding of the biology behind this complex ...
In May, I had the privilege of attending the 2025 Invest in ME Research International Conference in Cambridge, UK, along with OMF’s research Directors. This ...
Statistics 101 From the Desk of Dr. Danielle Meadows Vice President of Research Programs & Operations A few months ago, I started talking about evaluating ...
We’re pleased to share a new publication by Jonas Bergquist, MD, PhD, and colleagues: “Comprehensive transcriptome assessment in PBMC of post-COVID patients at two years after ...
From the Desk of Dr. Danielle MeadowsVice President of Research Programs & Operations The four major stages of the research process that I’ve laid out ...
As part of our May Momentum campaign, we are excited to share an interview with Chris Armstrong, PhD, and post-doctoral researcher, Kathy Huang, PhD, about their ...
Today, on International ME/CFS Awareness Day (May 12), we stand together to honor every person living with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)—a disabling, life-altering disease ...
As we approach ME/CFS Awareness Day on May 12, we reflect on the life-altering impact of this debilitating disease. Characterized by profound fatigue, cognitive impairment, ...
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
