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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada

The Ronald G. Tompkins Harvard
ME/CFS Collaboration

at the Harvard Affiliated Hospitals

Clinical and scientific studies to understand and discover new treatments for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS), Long COVID, and related Multisystem, Chronic Complex Diseases (msCCD).

About the research center

Dr. Wenzhong Xiao and Dr. David Systrom
Dr. Wenzhong Xiao and Dr. David Systrom

Established in 2018, this research initiative is based at Harvard affiliated hospitals, including Massachusetts General Hospital (MGH), Brigham and Women’s Hospital (BWH), and Beth Israel Deaconess Medical Center (BIDMC). 

Including the faculty of the Harvard affiliated hospitals, critical collaborations are represented from Stanford University, Cornell University, University of Birmingham, University of Nottingham, Uppsala University and Pacific Northwest National Laboratory. 

This collaborative research center was launched by Ronald G. Tompkins, MD, ScD, and Wenzhong Xiao, PhD. Dr. David Systrom took on the role of Co-Director with Dr. Xiao to continue Dr. Tompkins’ Legacy after his sudden passing in early 2022. This research collaboration seeks to understand and discover new treatments for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS), Long COVID, and related Multisystem, Chronic Complex Diseases (msCCD).

Core Aims


the underlying basis of post-exertional malaise and/or post-muscular stress


the role of neuroinflammation in ME/CFS



possible pathologies associated with ME/CFS patients


the role of circulation and autonomic issues in ME/CFS


efficiency of clinical visits for ME/CFS patients to significantly reduce wait times


the infrastructure to begin treatment trials and form a center of excellence for ME/CFS

Logo: the Harvard ME/CFS Collaboration

Fundamental Philosophy

  • Work collaboratively with other groups
  • Use the most advanced technology available to perform the research
  • Explore the research community to find experts in the areas to study
  • Take direct measures from ME/CFS patients to avoid artificial observations
  • Research multiple tissues of the body and consider stark differences of different cell types

View our latest news


The Life Improvement Trial (LIFT)

The Life Improvement Trial (LIFT) aims to investigate two drugs, separately and in combination, Pyridostigmine (commonly known as Mestinon) and Low-Dose Naltrexone (LDN), for efficacy and to research the difference between responders and non-responders.

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Scientific Team

Two women researchers cooperating in a lab

Massachusetts General Hospital

In Memoriam – Ronald Tompkins, MD, ScD

Wenzhong Xiao, PhD

Donna Felsenstein, MD

Amel Karaa, MD

Andrew Alexander, MBA

Peng Li, PhD

Karen Buch, MD

Brigham & Womens Hospital

David Systrom, MD

Anthony Komaroff, MD

BI Deaconess Medical Center

Janet Mullington, PhD

Boston University

Lewis Kazis, ScD

Mary Slavin, PhD

Pengsheng Ni, PhD

Bill Rogers, PhD

Pacific Northwest National Laboratory

Richard Smith, PhD

John Jacob, PhD

Wei-Jun Qian, PhD

Chiari Neurosurgical Center

Paolo Bologenese, MD

Ilene Ruhoy, MD

Center For Healing Neurology

David Koffman, MD

University of Nottingham, UK

Philip Atherton, PhD

Paul Greenhaff, PhD

Daniel Wilkinson, PhD

Mathew Piasecki, PhD

University of Birmingham, UK

Janet Lord, PhD

Cornell University

Maureen Hanson, PhD

Open Medicine Foundation

Linda Tannenbaum

Chris Armstrong, PhD

Stanford University

Ronald Davis, PhD

Uppsala University, Sweden

Jonas Bergquist, MD, PhD

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