Announcing OMF's First ME/CFS Clinical Trial!

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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada

Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Long COVID.

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Announcing The Ronald G. Tompkins Harvard ME/CFS Collaboration at the Harvard Affiliated Hospitals

To honor the memory of Ronald G. Tompkins, MD, ScD, we have a special announcement to share with the community. We have renamed the OMF funded Harvard ME/CFS Collaboration to The Ronald G. Tompkins Harvard ME/CFS Collaboration at the Harvard Affiliated Hospitals.

Dr. Tompkins was a brilliant and compassionate thought leader who passionately used his vast knowledge base and expertise to advance OMF funded research since he joined the OMF Scientific Advisory Board in 2014. Not only was he a gifted scientist and doctor, but he was a dedicated advocate for the patient community, committed to improving healthcare for all those impacted by related multisystem chronic, complex diseases (msCCD).

In 2018, OMF launched the ME/CFS Harvard Research Collaborative with Dr. Tompkins and Wenzhong Xiao, PhD as Co-Directors. The ultimate goal of this research iniative is to understand the underlying mechanisms and discover new treatments for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS), msCCD and now Long COVID.

At The Ronald G. Tompkins ME/CFS Collaboration, we remain committed to honoring Dr. Tompkins’s legacy by continuing his life’s work; to transform patient care, and ultimately, find a cure for all those living with chronic, complex diseases.  

Learn more about Dr. Tompkins’ life and legacy.

During this mourning period, we invite you to share your messages and memories of Dr. Tompkins on our KudoBoard. We hope this board will serve as a virtual memorial where we can come together as a community to reflect and honor Ron’s incredible legacy.

We will all miss him greatly but he will always be with us in our hearts.

With hope for all,
Linda Tannenbaum

Founder & CEO/President

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.