Announcing OMF's First ME/CFS Clinical Trial!

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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada

Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Long COVID.

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ME / CFS Collaborative Research Center at Uppsala University

We are proud to announce that OMF has funded the establishment of a third ME / CFS Collaborative Research Center, at Uppsala University in Sweden.

Jonas Bergquist, MD, PhD, in the Uppsala University lab.

The new Uppsala Center will be led by OMF Scientific Advisory Board member Jonas Bergquist, MD, PhD, and will work synergistically with the ME / CFS Collaborative Research Center at Stanford led by Ronald W. Davis, PhD, and the ME / CFS Collaborative Research Center at Massachusetts General Hospital and Harvard Affiliated Hospitals, led by Ronald G. Tompkins, MD, ScD, and Wenzhong Xiao, PhD, of Harvard University. All science funded by OMF continues to be under the overall direction of our Scientific Advisory Board, directed by Ron Davis.

This new Collaborative Center focuses on the targeted molecular diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) with the goal of evidence-based strategies for interventions. In Uppsala, significant efforts are being brought to bear on the analysis of cerebrospinal fluid as a unique source of neurochemical biomarkers of ME / CFS. High-resolution mass spectrometry will be used for extremely sensitive detection of endogenous biomolecules. This unique technology, in combination with the development of clinically relevant screening and targeted methods for sampling, will deliver previously unattainable insights into the pathophysiology of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS).

Uppsala University, Sweden
Jonas Bergquist, MD, PhD, Prof, Director
Kumari Ubhayasekhera, PhD
Annie Bynke, Med Student
Rizwan Muhammad, Guest Researcher
N.N. PhD Student
Torsten Gordh, MD, PhD, Prof em

Karolinska Institutet

Per Julin, MD, PhD

Anders Rehnström, PhD

Anna Lindquist, MD

Emelie Karlsson, RN

Bragee Clinics, Sweden

Bo C. Bertilsson, MD, PhD

Björn Bragée, MD

Gunnar Olsson, MD, PhD

Jonas Axelsson, MD, PhD

Britt Bragée, RPT, PhD

Gabriella Bernhoff, RPT, PhD student

Brandon Drum, Med Student

Michael Fahlqvist, MD – internship

Michos Anastasios, MD

Gottfries Clinic

CG Gottfries, MD, PhD

Linkoping University

Anders Rosén, MD, PhD

Björn Ingelsson, PhD

Eirini Apostoulo, PhD

Charite

Carmen Scheibenbogen, MD, PhD

University of East Anglia

Simon Carding, PhD

Learn more about the  ME / CFS Collaborative Research Center at Uppsala University here.

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Data Subject Access Request (DSAR) Form 

Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.