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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada

Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Long COVID.

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New publication from Dr. David Systrom & Colleagues!

New publication from Dr. David Systrom & Colleagues! 

 “Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-Acute Sequelae of SARS-CoV-2: More in Common Than Not?”

Read it now.
(Full article available as PDF)

OMF is proud to be one of the funders of this important publication!

 

Topic Importance: Long COVID (Post-Acute Sequelae of SARS-CoV-2, “PASC”) is a debilitating condition that often shares overlapping symptoms with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS), such as extreme fatigue, post-exertional malaise (PEM) and orthostatic intolerance. Scientists don’t fully understand why this happens.

Deconditioning has been suggested as a cause for exercise intolerance in these patients, but the results of Cardiopulmonary Exercise Testing (CPET) argue against it. Instead, issues with blood flow and oxygen use seem to be relevant.

 

This review aims to highlight the similarities between Long COVID and ME/CFS in terms of exercise-related issues, which could help guide future diagnostics and treatment for both conditions.

 

 

Open Medicine Foundation is committed to funding groundbreaking research and publications like this, which has the potential to improve the lives of millions of people suffering from ME/CFS, Long COVID, and related chronic, complex diseases.

Your support is crucial in accelerating research, advancing our understanding of these complex conditions, and ultimately finding effective diagnostics and treatments.

Please consider making a donation today to support our ongoing efforts. Every contribution, big or small, makes a significant impact on the lives of those affected by these debilitating conditions.

 

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.