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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada

Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Long COVID.

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Out Now! Itaconate Shunt Hypothesis Part 2 – Video Interview with Robert Phair & Janet Dafoe

Itaconate Shunt Hypothesis Part 2 
An Engaging Interview with Robert Phair & Janet Dafoe

 We are excited to share that the highly anticipated second installment of the Itaconate Shunt Hypothesis video is now available for viewing! 

WATCH NOW

 

 *Transcript available here  

This video interview, led by Janet Dafoe, PhD, features the research of Robert Phair, PhD. Together they delve deeper into the mechanisms of the itaconate shunt and its potential implications for the field of ME/CFS research.

The Itaconate project is a true testament to the power of patient-funded research. Thanks to the support of patients, OMF was able to invest over $900,000 to both Integrative Bioinformatics and Ron Davis’ team at Stanford in the foundational work that produced the initial theories in the field of metabolic traps and shunts.

We are beyond grateful to patients, their caregivers, and allies for their contribution and support in advancing this important area of research. We are so proud that we can provide opportunities for funding significantly impactful work through our global collaborative network of researchers.

Dr. Phair and Dr. Dafoe’s expertise and passion for the subject make for a truly informative and engaging viewing experience. We hope you enjoy it!

*Missed part 1 of the Itaconate Shunt Hypothesis or need a refresher?

Watch it here! 

Your support is vital! Your contributions help us continue funding significantly impactful work through our global collaborative network of researchers. Thank you for your support! 

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.