Announcing OMF's First ME/CFS Clinical Trial!

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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada

Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Long COVID.

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Person Role: Symposium 2018 Speaker

Raeka Aiyar, PhD | Symposium Moderator

Raeka Aiyar, PhD, is the Senior Director of Scientific Outreach at The New York Stem Cell Foundation Research Institute, and an experienced molecular biologist turned science communicator. Trained in genomics and bioinformatics at the University of Waterloo, she received her PhD at the European Molecular Biology Laboratory in Germany, where she investigated new therapeutic strategies […]

Robert Phair, PhD

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Dr. Robert Phair is an MIT electrical engineer who worked at the National Institutes of Health while in the US Public Health Service, earned a PhD in physiology at the University of Michigan, and was a dual professor of Biomedical Engineering and Physiology for 16 years at the Johns Hopkins School of Medicine before co-founding, […]

Michael Sikora

Michael Sikora is a PhD candidate in the Genetics department at Stanford University working in the lab of Lars Steinmetz. During his PhD he helped develop a method that permits precise selection of clonally expanded T cells for single cell RNA-seq. He is currently collaborating with the ME/CFS team at Stanford to apply this method […]

Øystein Fluge, MD, PhD

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Dr. Fluge has been courageous in pursuing his observations on the effects of rituximab on ME/CFS patients when that issue was not the planned focus of his investigation. He has now completed a double-blind, well-controlled, multi-center clinical trial on the effects of Rituxamab. He has continued to follow where the data lead him into cellular and […]

Jarred Younger, PhD

Jarred Younger obtained his PhD in Experimental Psychophysiology at the University of Tennessee in Knoxville in 2003. He then completed postdoctoral fellowships in pain medicine and neuroimaging at Arizona State University and Stanford University before joining the faculty at Stanford in 2009. In 2014, he transferred to the University of Alabama at Birmingham, where he […]

Alain Moreau, PhD

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Dr. Alain Moreau is a Full Professor in the Faculty of Dentistry (Stomatology Department), cross-appointed to the Biochemistry and Molecular Medicine Department in the Faculty of Medicine at Université de Montréal. He served as Director of Research and Chief Scientific Officer of Sainte-Justine University Hospital (2013-2016). He is currently Director of The Network for Canadian […]

Wenzhong Xiao, PhD

As a world expert in computational genomics, Dr. Xiao develops bioinformatic and statistical tools for use in understanding human diseases, especially in studies of immuno-metabolic response. He focuses on integrative analysis and interpretation of multi-dimensional molecular, cellular, and clinical data of many types of patients, including those with ME/CFS. Dr. Xiao’s expertise will be essential for the […]

In Loving Memory of Ronald G. Tompkins, MD, ScD

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Sumner M. Redstone Professor of Surgery, Harvard Medical School Founding Director, Center for Surgery, Innovation & Bioengineering, Massachusetts General Hospital Former Co-Director, OMF-sponsored ME/CFS Collaboration at the Harvard-Affiliated Hospitals, Harvard Medical School, Massachusetts General Hospital September 24, 1951- January 17, 2022 Dr. Ronald Tompkins’s work in the genomics, proteomics, and ultrastructural roles in inflammation and metabolism, and […]

Maureen Hanson, PhD

Maureen Hanson, headshot

Dr. Hanson has conducted groundbreaking molecular analysis of many facets of ME/CFS. She analyzes her data with sophistication and insight. It’s exciting to have such an accomplished top-notch scientist working on this disease. Dr. Hanson is the Liberty Hyde Bailey Professor in the Department of Molecular Biology and Genetics at Cornell University. She previously was on […]

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.