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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada
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Research Portfolio in Review: Last Day to Donate in 2024!

Time is running out! With just a couple of hours in 2024 left, your year-end gift can help launch groundbreaking research initiatives in 2025. Our scientists are poised to build on this year’s momentum—will you help drive their work forward?

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2024 Research Portfolio in Review

Infographic with the following stats: 35+ active research projects, 3 treatment projects, 6 publications, 3 preprints, 11200+ participants in StudyME, 13 studies recruiting via StudyME.

In Case You Missed It: Interviews with OMF’s Directors

David Systrom, headshot

David Systrom, MD

A Muscle Biopsy Study to Understand the Molecular Mechanisms of PEM

Alain Moreau, PhD

Deep Proteome and Metabolome Profiling to Decode Myalgic Encephalomyelitis (DOMINO-ME)

Jonas Bergquist headshot

Jonas Bergquist, MD, PhD

Assessing Neuroinflammatory Involvement in ME/CFS via MRI and PET

Chris Armstrong, PhD

Linking Brain Blood Flow, Neuroinflammation, Metabolism, and Hormones in ME/CFS, POTS, and Long COVID

Ron Davis, PhD Headshot

Ron Davis, PhD

Neutrophil Assessment Platform

Wenzhong Xiao, PhD

Computation Approaches: Traditional Data Analysis and Knowledge-Based Network Analysis

Coming in 2025: Science Wednesdays

Starting January 1, 2025, OMF Canada will be introducing Science Wednesdays. Every Wednesday (based on North American time zones), tune in to our social media to read a little bit about pieces of science, research, and technology that connect to OMFCA’s ME/CFS and Long COVID research projects.

Will you help OMFCA push research further and faster? Your gift today will power our vital research into 2025.

Donate Now

As we turn the page to a new year, we remain hopeful for a brighter future for those living with ME/CFS and Long COVID. Thank you for your unwavering support in 2024 and beyond.

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.