Red Blood Cell Deformability in ME/CFS (RBC Biomechanics)
The goal of the project is to develop, characterize, and validate a microfluidic chip for the estimation of biomechanical properties of red blood cells (RBCs) isolated from ME/CFS patients vis-à-vis healthy controls.
Genetic and Metabolic Markers of BH4 Deficiency in Long COVID
This project aims to test whether
genetic markers and other indicators of BH4 deficiency are also present in subjects with Long COVID.
Investigation into Post-Exertional Malaise Between Historical and Recent ME/CFS
The study expands on a previously-awarded proposal to thoroughly explore the underlying pathophysiology of post exertional malaise (PEM), the hallmark symptom of ME/CFS.
Long COVID to ME/CFS Study
OMF secured a $1 million grant to launch the first year of an international, multi-year study across the six OMF supported Collaborative Research Centers (CRC). The aim of this study is to examine Long COVID transitioning to ME/CFS.
Single Day Longitudinal Study
This study seeks to understand the biological mechanisms driving the symptomatology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using metabolomic and lipidomic high-throughput analysis and high-frequency blood sampling over a 6.5 to 7.5 hour period conducted at two separate sites (Melbourne and Uppsala).
Metabolic Differentiation of ME/CFS Comorbidities
To investigate the metabolite signatures of ME/CFS patient stool, urine and blood samples and the impact that co-morbidities (IBS and Fibromyalgia) have on these signatures.
Biological Outlier and Subtyping Software for Myalgic Encephalomyelitis
This project will develop a software tool to rapidly look for metabolism anomalies in an individual which might be explained by their genes. It will also look for potentially damaging genes in individuals and it will attempt to group ME/CFS patients based on their genetic and metabolic profiles.
Cellular Nitrogen and Energy Metabolism in ME/CFS
This project aims to test the nitrogen hypothesis, which is that damaging, nitrogen-containing by-products of energy metabolism accumulate more readily in the cells of ME/CFS patients.
RAman SPectrometry Based biomarkER discoveRY for Myalgic Encephalomyelitis (RASPBERRY-ME)
The overarching goal of RASPBERRY-ME project is the characterization of the biomolecular signature of Myalgic Encephalomyelitis using Label-free Raman Spectroscopy (RS) and machine learning models.
Study of COVID-19 survivors’ profiles for detection of ME/CFS (SCOPIMED)
The purpose of this study is to capture a post-COVID-19 infected population willing to participate in phenotyping studies early in the post-COVID-19 illness progression, with an aim of providing targeted effective therapies and preventing the onset and progression of ME/CFS.
