Long COVID to ME/CFS Study

OMF secured a $1 million grant to launch the first year of an international, multi-year study across the six OMF supported Collaborative Research Centers (CRC). The aim of this study is to examine Long COVID transitioning to ME/CFS.

Single Day Longitudinal Study

This study seeks to understand the biological mechanisms driving the symptomatology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using metabolomic and lipidomic high-throughput analysis and high-frequency blood sampling over a 6.5 to 7.5 hour period conducted at two separate sites (Melbourne and Uppsala).

Itaconate Trap Study

This project aims to look at metabolic traps in central carbon metabolism that lead to observed altered energy production pathways in ME/CFS.

Biological Outlier and Subtyping Software for Myalgic Encephalomyelitis

This project will develop a software tool to rapidly look for metabolism anomalies in an individual which might be explained by their genes. It will also look for potentially damaging genes in individuals and it will attempt to group ME/CFS patients based on their genetic and metabolic profiles.

Multi-Omics Study of ME/CFS (MAESTRO)

The primary goal of this project is to complete our comprehensive analysis of the genome, methylome, miRnome, and their interactions in order to fill the gaps in our understanding of ME/CFS pathophysiology and to identify clinically useful biomarkers.