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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada

Crash-Course: Studying PEM/flares in ME/CFS, PTLDS, Long COVID

a close-up of a finger with a drop of blood on it, against a white background.

The study aims to compare biological markers during mild symptoms and flare/PEM events in individuals with ME/CFS, alongside PTLDS and Long COVID patients, using finger-prick blood samples and continuous data from wearable sensors to understand symptom variability.

The Life Improvement Trial (LIFT)

Headshots of Jonas Bergquist and David Systrom alongside the text “The LIFT.”

The Life Improvement Trial (LIFT) aims to investigate two drugs, separately and in combination, Pyridostigmine (commonly known as Mestinon) and Low-Dose Naltrexone (LDN), for efficacy and to research the difference between responders and non-responders.

Temporally Resolved Omics Tracking of ME/CFS

Woman researcher doing a blood test

This study seeks to understand the biological mechanisms driving the symptomatology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using metabolomic and lipidomic high-throughput analysis and high-frequency blood sampling over a 6.5 to 7.5 hour period conducted at two separate sites (Melbourne and Uppsala).

iCPET Omics Studies of ME/CFS

This Harvard study evaluates the different explanations of heart preload failure in ME/CFS patients to determine which is active in many, if not all, ME/CFS patients. The Computation Center is now seeking to better understand the causes of ME/CFS (PLF, the high flow type) as well as to identify potential drug targets for future therapies.

OMF Data Center

The purpose of the OMF Data Center is to house raw data and processed results, which is shared with our research network through the web-based data portal.

Skeletal Muscle Dysfunction

This project aims to explore the biological changes that occur in the muscles during Post-exertional Malaise (PEM).


OMF secured a $1 million grant to launch the first year of an international, multi-year study across the six OMF supported Collaborative Research Centers (CRC). The aim of this study is to examine Long COVID transitioning to ME/CFS.