This study seeks to understand the biological mechanisms driving the symptomatology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using metabolomic and lipidomic high-throughput analysis and high-frequency blood sampling over a 6.5 to 7.5 hour period conducted at two separate sites (Melbourne and Uppsala).
To investigate the metabolite signatures of ME/CFS patient stool, urine and blood samples and the impact that co-morbidities (IBS and Fibromyalgia) have on these signatures.
This project aims to look at metabolic traps in central carbon metabolism that lead to observed altered energy production pathways in ME/CFS.
This project will develop a software tool to rapidly look for metabolism anomalies in an individual which might be explained by their genes. It will also look for potentially damaging genes in individuals and it will attempt to group ME/CFS patients based on their genetic and metabolic profiles.
The study aims to establish a condensed personalized research protocol that can be used to characterize ME/CFS in individual patients as it pertains to all their unique biological aspects, interacting with a complex chronic disease.
This project aims to test the nitrogen hypothesis, which is that damaging, nitrogen-containing by-products of energy metabolism accumulate more readily in the cells of ME/CFS patients.
Ocular Motor Study Study AIM The aim of this project is to fully characterise eye movement changes in ME/CFS on two consecutive days, identifying an ocular motor signature that is unique to the disorder. LEAD INVESTIGATORS Christopher Armstrong, PhD Joanne Fielding Meaghan Clough Updates and Potential Currently recruiting participants for this study. Preliminary trials on […]
This proposal seeks to understand pathological mechanisms of pediatric ME/CFS (13 to 18 years old).
Deep Proteome and Metabolome Profiling Study AIM Collaborate with OMF CRCs in Uppsala and Melbourne to establish a global perspective. Decode the molecular mechanisms underlying ME/CFS and contributing to specific symptoms with a particular emphasis of post-exertional malaise (PEM) through: Deep phenotyping of ME patients Global proteomic plasma profiling of ME patients Global metabolomics plasma […]
The study aims to establish an analytical workflow for outlier analysis in ME/CFS and develop a software program to rapidly identify these potential anomalies.