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Category: News

Honor Your Loved Ones with the Gift of Hope and Research ❤️

We understand that traditional holiday gatherings aren’t always possible for many in our community. But there is a meaningful way to show your love and support from wherever you are.  By making a tribute gift to OMF Canada, you can honor someone special in your life who has been affected by ME/CFS or Long COVID […]

Record-Breaking Triple Giving November: Thank You

An announcement graphic with blue balloons and confetti on a light background. The text reads “Over $3M Raised” in large blue letters, with “Thank You” written below in a script font.

Thank you to our extraordinary OMF community for making this year’s Triple Giving November truly record-breaking. We are thrilled to share that our Triple Giving November campaign raised over $3 million this year! Because of the remarkable generosity of our leadership donors every gift was tripled. We received more than 1,800 donations from our OMF […]

🧬Science Wednesdays: What is Stratification?

Hands using a laptop next to a stethoscope, overlaid with medical icons and an ECG line, illustrating medical research.

What is Stratification? From the Desk of Dr. Danielle MeadowsVice President of Research Programs & Operations To round out my first year of Science Wednesdays, I wanted to talk a bit about a concept that helps address the heterogeneity of ME/CFS—stratification. This is such an important concept in complex research it actually spans both of […]

Exploring a genetic basis for the metabolic perturbations in ME/CFS using UK Biobank

Dr. Chris Armstrong, the Director of OMF’s Melbourne ME/CFS Collaboration, and his team recently published a paper on their work looking at which genes were most impactful to metabolites in ME/CFS and which were most impactful in controls.  When comparing the genes identified between the two groups, two related to cortisol production were found to […]

OMF Directors Interview & Final Hours to Triple Your Gift

Today is International Giving Tuesday, marking the final hours of our Triple Giving November campaign! There are just a FEW HOURS LEFT to have your donation tripled. Don’t wait—now is the time to give! All donations will be tripled up to $1,000,000! Triple My Gift As we near the close of this powerful campaign, we’re […]

Only 48 Hours—Make Every Gift Count 3x

ME/CFS remains one of the most invalidated and underdiagnosed diseases in modern medicine. Despite affecting millions worldwide, there is still no FDA-approved diagnostic test. Instead, patients endure years of uncertainty, misdiagnosis, and medical dismissal as they navigate the uncertain journey toward validation and care. In case you missed it, this video highlights individuals from around […]

An Interview with Chris Armstrong, PhD, and Wenzhong Xiao, PhD

In today’s interview, Dr. Chris Armstrong and Dr. Wenzhong Xiao, two of OMF’s Directors, talk about what they think is going on in ME/CFS, including differences in producing energy and the immune and central nervous systems being out of balance. They also discuss connections between their research. Remember — from November 1 to December 2, […]

Introducing OMF Journal Club

From the Desk of Dr. Danielle MeadowsVice President of Research Programs & Operations I wanted to take a quick moment to highlight opportunities for you all to interact with some of us at OMF, and to share the list of our peer-reviewed publications produced to date in case you’ve missed them. When it comes to […]

An Interview with Jonas Bergquist, MD, PhD, and Alain Moreau, PhD

Today, we’re excited to share an interview with Dr. Jonas Bergquist and Dr. Alain Moreau. In this discussion, both OMF Directors draw connections between their research and share their main ideas about ME/CFS. Until December 2, 2025, EVERY dollar you give to OMF Canada will be TRIPLED!We’re excited to announce that a generous donor has […]

From OMF’s CEO, Linda Tannenbaum: A Message of Hope and Action

At OMF Canada (OMFCA), our purpose is clear: to revolutionize the way we understand and treat chronic complex multi-system diseases, with initial focus on ME/CFS and Long COVID, by illuminating their mechanisms, accelerating effective treatments, and empowering personalized care. Our mission is to drive and fund global collaborative research that unlocks disease biology, delivers precise […]

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.