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Category: News

Computation Approaches: Traditional Data Analysis and Knowledge-Based Network Analysis

Dr. Wenzhong Xiao standing in front of a colorful, science-themed background.

In the final installment of our series with OMF directors, we bring you an illuminating interview with Wenzhong Xiao, PhD, Director of OMF’s Computational Research Center for Complex Diseases. Dr. Xiao performs data analysis for many of OMF’s clinical studies in addition to knowledge-based network analysis. Computation Approaches: Traditional Data Analysis and Knowledge-Based Network Analysis […]

Discriminating ME/CFS and Comorbid Conditions Using NMR Metabolomics in UK Biobank

The image depicts the skyline of Melbourne, Australia. Prominent modern skyscrapers are visible in the background, showcasing the city's architectural diversity.

Today, we are excited to share a new publication by Christopher Armstrong, PhD, & colleagues: “Discriminating ME/CFS and Comorbid Conditions Using NMR Metabolomics in UK Biobank.” The Heart of the Matter The OMF Melbourne ME/CFS Collaboration recently published an article on their project using metabolomics to identify ME/CFS. The team analyzed metabolomics data on over […]

Interview with Ron Davis, PhD: Last Chance to Triple Your Impact!

Ron Davis, who has short gray hair and is wearing a light green collared shirt and glasses.

Today is International Giving Tuesday, marking the final hours of our Triple Giving November campaign! There are just a FEW HOURS LEFT to have your donation tripled. Don’t wait—now is the time to give! Triple My Gift As we near the close of this powerful campaign, we’re excited to share an interview with Ron Davis, […]

Patient-Reported Treatment Outcomes in ME/CFS and Long COVID

OMF Canada Triple Giving November logo

We are pleased to share a new preprint by Wenzhong Xiao, PhD & Martha Eckey, PharmD: “Patient-Reported Treatment Outcomes in ME/CFS and Long COVID.” With only TWO DAYS LEFT in Triple Giving November, now is a powerful time to make a difference. With your help, we can leverage this triple-matching opportunity to its fullest potential. […]

“The Water Will Always Be There” by Claire Ingram

The image depicts a serene woodland scene with tall trees scattered throughout. The background features a small reflective body of water surrounded by lush greenery and dense foliage.

Until December 3, 2024, EVERY dollar you give to OMF Canada will be TRIPLED, up to $500,000. Donate now for a 3X match Imagine for a moment, the sun on your face, the gentle rustle of leaves, and the profound peace that comes from a quiet moment in nature. For Claire, this was a distant […]

Assessing Neuroinflammatory Involvement in ME/CFS via MRI and PET: Interview with Dr. Bergquist

Jonas Bergquist headshot

Today, we present an exclusive interview with Jonas Bergquist, MD, PhD, from the OMF Collaborative Center at Uppsala, who shares insights on neuroinflammatory involvement in ME/CFS.  As we reach the halfway point of OMFCA’s Triple Giving November campaign, remember that every donation is tripled. Please consider supporting OMFCA’s important research efforts. Triple My Gift Assessing […]

From Darkness to Light: The Moothart Brothers’ Journey

The image is divided into two sections. Left: Thomas is standing next to a large Totoro mascot at a comic convention, wearing a yellow cap and a lanyard with an event badge. Right: Josiah is sitting on the floor, petting a large dog that is lying on a furry blanket. Josiah is wearing glasses and a green hoodie with the word "Volunteer" partially visible.

Triple Your Impact When we first shared the Moothart family’s story two years ago, they faced the unimaginable: having two children, Thomas and Josiah, severely affected by ME/CFS at the same time. The bright futures they once envisioned seemed to fade away, replaced by the daily struggle with debilitating symptoms.  At that time, Thomas had […]

Meet Rebecca: A Journey of Resilience and Advocacy for ME/CFS

Picture of Rebecca with long, light hair, wearing a white jacket over a dark top. She is indoors, and there is a floor lamp and a framed picture visible in the background, contributing to a cozy and softly lit atmosphere.

As part of Triple Giving November, we are highlighting inspiring individuals whose journeys have made an extraordinary impact. Meet Rebecca, a dedicated advocate for ME/CFS and Long COVID research and a former OMF team member. Don’t forget! Your $50 donation will triple to $150, $100 becomes $300, and $250 turns into $750. Help fund critical research […]

A Muscle Biopsy Study to Understand the Molecular Mechanisms of PEM

David Systrom, headshot

As part of our Triple Giving November campaign, we are excited to share an interview with David Systrom, MD, discussing a muscle biopsy study aimed at understanding the molecular mechanisms behind Post-Exertional Malaise (PEM). Triple My Gift A Muscle Biopsy Study to Understand the Molecular Mechanisms of PEM Watch Now The Heart of the Matter Post-exertional malaise (PEM) […]

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.