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Category: Stanford News

Ron Davis ME/CFS Research Update DNA/RNA Technology with Peidong Shen, PhD

Ron Davis ME/CFS Research Update DNA/RNA Technology with Peidong Shen, PhD We’re pleased to present the next video in our series of research updates, led by advocate and caregiver Janet Dafoe, PhD. Today, Ron Davis, PhD, sits down to discuss how DNA & RNA technology is being developed and used at Stanford to advance research […]

Ron Davis Updates on the Metabolic Trap!

Ron Davis Updates on the Metabolic Trap!  From the Desk of Ronald W. Davis, PhD:  I’m pleased to be doing this series of interviews posted on OMF’s website and social media. This new video update about the Metabolic Trap Hypothesis is especially exciting because we’ve made significant progress lately that I’ve been looking forward to reporting […]

NEW Update from Ron Davis: The Manganese Study

NEW Update from Ron Davis! The Manganese Study Today, we are delighted to share the next video in our series of research updates from Ronald W. Davis, PhD, Chair of OMF Scientific Advisory Board & Director of the OMF supported ME/CFS Collaborative Research Center at Stanford. Due to the tremendous generosity of you, our patient […]

Exciting Updates from Ronald W. Davis, Ph.D!

From the Desk of Ronald W. Davis, Ph.D.,Chair of Open Medicine Foundation (OMF) Scientific Advisory Board I am honored to share that my research into Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) has been featured by People Magazine! This feature details my family’s personal struggle to find treatments or a cure for my son Whitney, […]

$1 Million Received to Study COVID-19 to ME/CFS

#TripleGivingTuesday Research Update $1 Million Received to Study COVID-19 to ME/CFS Open Medicine Foundation (OMF) is thrilled to announce an anonymous, $1,000,000 grant to fund a collaborative investigation of the relationship between COVID-19 and the possible trajectory to Myalgic Encephalomyelitis /Chronic Fatigue Syndrome (ME/CFS.) The study will be conducted at the internationally-based OMF funded Collaborative […]

Ron Davis Update

“We are doing everything we can to continue progress on Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS)during this time when we can’t go into the lab. This is a photo of me on a zoom conference call with doctors and researchers from across the country and Europe planning for a test of a […]

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.