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Types of Outcome Measures From the Desk of Dr. Danielle Meadows, Vice President of Research Programs & Operations In an effort to talk a little more about the nuances of the research process, last month I honed in on an aspect of “Study Design, IRB/Ethics Review”: well-powered studies. This month, I want to shift slightly […]

Understanding Post Exertional Malaise (PEM) in ME/CFS | OMF

Post-exertional malaise (PEM) is a defining symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), marked by a significant worsening of symptoms or the development of flu-like symptoms following physical or mental exertion. PEM can be triggered by even minimal activity and lead to severe and prolonged debilitation. Key Characteristics of Post-Exertional Malaise PEM manifests as a […]

Message from Anna: Finding Hope in Community!

  Dear OMFCA Community, My name is Anna Carina, and I live with my family in Vaxholm, Sweden. In 2016, our son Lucas fell ill with ME/CFS after having a glandular fever at the age of 13. We went through the same story of disbelief, stigmatization, and blame that many of you have also experienced.    […]

Charlotte’s Voice: A Personal Journey with ME/CFS!

Char's picture with a quote: “I was only fourteen when ME/CFS took over my life. I now join thousands of others in supporting OMF in their research to help improve the lives of millions across the world."

Today, we are privileged to bring you the narrative of extraordinary courage, resilience, and strength. At just 14 years old, Charlotte’s life took an unexpected turn with a diagnosis of ME/CFS.    Read Charlotte’s story in her own words:   “My name is Charlotte; I am 18 years old, and I have been living with […]

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Open Medicine Foundation (OMF) is proud to share details of a new OMF-funded publication from Christopher Armstrong, Ph.D., and colleagues: “In vitro B cell experiments explore the role of CD24, CD38 and energy metabolism in ME/CFS.” Read now!   From the Desk of Dr. Armstrong, Director of the OMF SupportedMelbourne ME/CFS Collaboration:  In this paper, we […]

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.