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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada

Extended Big Data Study in Families

  • Published a paper on the characteristics of immune cells in ME/CFS (read here).
  • Continuing to collect longitudinal samples from patients, their unaffected family members and healthy volunteers.
  • Functional studies such as immunostaining, western blot, and RTCPR/PCR, in progress.
  • DNA and RNA extraction for whole genome, transcriptome, and DNA methylation studies in progress.
  • Two manuscripts under preparation on ME/CFS autoantibody profiling and ME/CFS plasma proteomics and cytokine landscape, which are aimed to be published in 2023.

STUDY HYPOTHESIS AND DESCRIPTION

In 2016, Fereshteh Jahanbani collaborated with Ron Davis and Mike Snyder to launch a study with the aim of deepening our understanding of how genetic and epigenetic variations impact our health, including our susceptibility to complex diseases such as ME/CFS and related comorbidities and multimorbidities.

The study was designed with the rationale that using unaffected family members as a control group would enable researchers to identify genetic and environmental risk factors that are associated with disease development, while longitudinal multi omics profiling could help to identify biomarkers and therapeutic strategies.

 OBJECTIVES