Announcing OMF's First ME/CFS Clinical Trial!

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Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Long COVID.

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You are the Motivation
behind our Momentum

Your support is the driver of the End ME/CFS Project. Your donations spur our research and progress. Because of you, OMF has built a global network of brilliant researchers dedicated to finding a cure.

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You are the Motivation
behind our Momentum

Your support is the driver of the End ME/CFS Project. Your donations spur our research and progress. Because of you, OMF has built a global network of brilliant researchers dedicated to finding a cure.

donate now

The challenges are real, but we won’t lose momentum. Not with you on our team.

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Research Gains Momentum

Support our annual May Momentum Campaign, and fund research into groundbreaking treatments and a cure for Myalgic Encephalomyelitis / chronic fatigue syndrome (ME / CFS). Since its inception, OMF has raised over $24 Million for ME / CFS research from private donors, making us the worldu2019s largest ME / CFS research private funder. Will you please support our annual May Momentum Campaign today, and help OMF keep up the momentum to find answers, treatments and a cure for ME / CFS?  With you on our team, we all have a reason to be hopeful!

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Your contribution funds open and collaborative researchers who are working every day to help all ME / CFS patients have a healthier tomorrow.
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We are announcing

THREE
major research projects throughout May!

OMF forges partnerships

between many of the world's leading ME / CFS researchers

We fund research projects with real-life implications for ME / CFS sufferers.

OMF is funding two exciting pilot treatment trials, Mestinon and Kynurenine. The outcome of this research will be to determine what biological factors might be relevant to their success or failure at treating the symptoms of people diagnosed with ME / CFS. Ultimately the data generated will help to better understand the pathogenesis of ME / CFS towards finding effective treatments.

In a rapid response to the recent COVID-19 pandemic, Open Medicine Foundation has launched a study to track patients with COVID-19 that have been discharged from the ICU, with the expectation that some will develop ME / CFS. The tracking of these participants will involve sample collection for testing of biological factors, continuous health tracking via wearables and symptom data collection for many separate timepoints over the course of two years.

This presents an unprecedented opportunity to study the biological factors that differentiate why some people develop ME / CFS following infection and why some people recover completely.

New Research Projects

Study of the possible conversion of COVID-19 patients to ME / CFS
Open Medicine Foundation is excited to announce the initiation of a study of patients with COVID-19 to monitor the course of their disease and its ...
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Mestinon Clinical Trial
This clinical trial will test the exercise response to Mestinon in people with ME/CFS.
Read More
Kynurenine Clinical Trial for ME / CFS
Open Medicine Foundation is excited to announce its support of an initiation of a clinical trial to understand potential disturbances in the tryptophan metabolism and ...
Read More
Learn more about the End ME/CFS Project

You are the Motivation
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Images generously submitted by people with ME / CFS for #FlashbackFriday. Thank You!

Consent management

Consent Preferences

Data Subject Access Request (DSAR) Form 

Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”