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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada
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Introducing OMF Journal Club

From the Desk of Dr. Danielle Meadows
Vice President of Research Programs & Operations

The image features Danielle Meadows with shoulder-length brown hair, wearing a dark blazer and a green top.

I wanted to take a quick moment to highlight opportunities for you all to interact with some of us at OMF, and to share the list of our peer-reviewed publications produced to date in case you’ve missed them.

When it comes to sharing information about OMF’s research with you all, I am continually trying to improve the amount of information we share, the timeliness of sharing it, and the accessibility of the content. So to that end, I want to briefly introduce a new style of research communications that I plan on starting (on a trial basis) in 2026 when OMF publishes a research paper. 

A close-up low-angle view of a stack of journals on a desk. One issue is open on top.

I’m calling this OMF Journal Club, and the basic idea is that when one of our centers publishes results from their research, I will host a live discussion about that paper. I’ll try to walk through the main ideas of the paper, the figures, and the implications for people with ME/CFS and Long COVID. So keep an eye out for the next research publication, which will include more information about how to join the first session of OMF Journal Club. I look forward to connecting with you in the new year!

So far in 2025, OMF researchers have published 15 peer-reviewed papers, ranging from computational analysis of patient-reported treatment outcomes, to molecular basis for precision medicine approaches, to the development of new potential diagnostic tools, and more. To see the full list of OMF publications, click here.

Have questions about OMF’s publications, other aspects of our research projects, or OMF as a whole?

On January 21 at 1:00pm ET, Linda Tannenbaum (CEO and Founder) and Danielle Meadows, PhD (VP of Research Programs & Operations) will host a webinar with the objective of answering your questions about OMF and its research. If you’d like to be a part of the conversation, you can submit your questions and register for the webinar “Inside OMF: Your Questions, Our Answers” below.

Register for the Webinar
Submit a Question

If you’re unable to join the session live, feel free to submit your questions and we will send a recording after the session.

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This Triple Giving November, you have a unique opportunity to multiply your impact and accelerate research that brings us closer to understanding and treating ME/CFS and Long COVID.

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.