As we approach ME/CFS Awareness Day on May 12, we reflect on the life-altering impact of this debilitating disease. Characterized by profound fatigue, cognitive impairment, ...
As Open Medicine Foundation (OMF) begins its thirteenth year, we recently marked a significant milestone – the fourth anniversary of Open Medicine Foundation (OMF) Australia ...
Caring for patients with ME/CFS and Long COVID presents complex challenges—often leaving providers without clear, evidence-based guidance. That’s where the Medical Education Resource Center (MERC)—a ...
We are pleased to announce that Open Medicine Foundation (OMF) will attend the annual International ME Conference Week hosted by the UK charity Invest in ...
If you’re looking to drive meaningful change in the diagnosis and treatment of ME/CFS, Long COVID, and related conditions, the Medical Education Resource Center (MERC) ...
What is Metabolomics? From the Desk of Dr. Danielle, Meadows Vice President of Research Programs & Operations There are a lot of different kinds of ...
We envision a world where ME/CFS-informed clinicians are accessible to all. That’s why Open Medicine Foundation (OMF) and Bateman Horne Center (BHC) partnered to create ...
For nearly three years, Open Medicine Foundation (OMF) and Bateman Horne Center (BHC) have been working together to bridge critical gaps in medical education for ...
We’re pleased to share a new publication by Jonas Bergquist, MD, PhD, and colleagues: Targeted analysis of seven selected tryptophan-melatonin metabolites: Simultaneous quantification of plasma analytes ...
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
