Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Post COVID .

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Stand-up Comedian Shines Spotlight on ME/CFS

Stand-up comedian Doug Ouimette shines a spotlight on ME/CFS to raise awareness for wife.

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Exclusive: Ryan Prior Talks Upcoming Book, The Long Haul

OMF sat down with journalist, producer & patient activist Ryan Prior to chat about his upcoming book, The Long Haul

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Survey Participation Request: ME/CFS Survey from The Norwegian ME Association

Please help the Norwegian ME Association gather crucial information about ME/CFS by filling out their survey!

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Single Day Longitudinal Study

This study seeks to understand the biological mechanisms driving the symptomatology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using metabolomic and lipidomic high-throughput analysis and high-frequency blood sampling over a 6.5 to 7.5 hour period conducted at two separate sites (Melbourne and Uppsala).

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OMF Featured in Inside Philanthropy!

Open Medicine Foundation is proud to share that our work has been featured in Inside Philanthropy, a leading source of nonprofit news: “Boosting Research into Long COVID and ME/CFS.”

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OMFCA Honors Severe ME Day 2022

August 8, 2022, marks Severe ME/CFS Day. On this day of recognition, Open Medicine Foundation shines a bright light on all those who live in darkness.

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Big News! Announcing our 7th Center in Partnership with Bateman Horne Center

Open Medicine Foundation announces the launch of a new center to advance ME/CFS medical education in partnership with Bateman Horne Center!

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Ron Davis ME/CFS Research Update DNA/RNA Technology with Peidong Shen, PhD

Ron Davis ME/CFS Research Update DNA/RNA Technology with Peidong Shen, PhD We’re pleased to present the next video in our series of research updates, led …

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Video Update from Rob Phair: The Itaconate Shunt Hypothesis for ME/CFS

Robert Phair, PhD gives a video update on the Itaconate Shunt Hypothesis for ME/CFS, a study in collaboration with Christopher W. Armstrong, Ron Davis, PhD, and Ron’s team at Stanford.

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NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.