Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Post COVID .

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Medical Education Momentum is Happening!

Read about the latest ME/CFS medical education initiatives supported by Open Medicine Foundation!

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Spread Awareness, Share Hope: ME/CFS Awareness Day

may-12-2023

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Ultramarathoner to Long COVID Warrior: Beth’s Story

Discover Beth’s journey from ultramarathoner to Long COVID warrior, as she raises awareness of post-viral illness & Open Medicine Foundation’s research

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OMF’s StudyME Registry – Be Counted!

Volunteer for research! Join OMF’s free StudyME registry to accelerate ME/CFS, Long COVID & Fibromyalgia research.

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New publication from Dr. David Systrom & Colleagues!

Discover the similarities between Long COVID and ME/CFS exercise-related issues in this groundbreaking publication from Dr. David Systrom and colleagues.

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Join the Hope Builder Challenge – Help Us Reach Our Goal by March 31st!

The clock is ticking! We are asking for YOUR help to achieve our goal of 30 new Hope Builders in our monthly donor program by March 31

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Have you seen this exciting research?

OMF is leading exciting research that will benefit people with ME/CFS and Long COVID.

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Special Request! Join OMFCA’s Hope Builders Community

Introducing April: An artist, person with ME/CFS, & OMF Hope Builder.

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Out Now! Itaconate Shunt Hypothesis Part 2 – Video Interview with Robert Phair & Janet Dafoe

Discover the latest advancements in ME/CFS research with the second installment of the Itaconate Shunt Hypothesis video, with Robert Phair PhD and Janet Dafoe, PhD

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.