Temporally Resolved Omics Tracking of ME/CFS
This study seeks to understand the biological mechanisms driving the symptomatology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using metabolomic and lipidomic high-throughput analysis and high-frequency blood sampling over a 6.5 to 7.5 hour period conducted at two separate sites (Melbourne and Uppsala).
Critical Illness, Mechanisms of Recovery, Similarities to ME/CFS
We propose an initial explanation for how ME/CFS could originate and perpetuate by drawing on findings from critical illness and heat stroke research.
Studying CSF to further reveal pathogenesis mechanisms in ME/CFS
The goal of this research is to reveal more information about the role of immunology and neuroinflammation in ME/CFS, and the underlying mechanisms of related pathogenesis that takes place.
Long COVID Clinic Studies
The clinic in Uppsala continues the work of the OMF-Funded MultiCenter Collaborative Study on COVID to ME/CFS progression.
Home Visit Study
This study provides a unique opportunity to bring the lab directly into patient homes and provide immediate analysis of samples over an extended period of time.
This longitudinal approach without the invasive and/or PEM-induced measures will be vitally important in other patient cohorts and will decrease the study impact on patients from using more invasive and impactful measures (use of 1 peripheral vein catheter for all blood samples, limits the impact on patients).
Deep Proteome and Metabolome Profiling
Decode the molecular mechanisms underlying ME/CFS and contributing to specific symptoms with a particular emphasis of post-exertional malaise (PEM). This includes deep phenotyping of ME patients and global proteomic/metabolomics plasma profiling of ME..
Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS by Jonas Bergquist, MD, PhD, Uppsala Collaboration
The publication describes the overlaps between prolonged critical illness and ME/CFS. The hypothesis is that mechanisms that prevent recovery in some intensive care unit patients may also underlie people with ME/CFS.
Autoimmunity and Autoantibodies
The aim is to investigate potential differences in adrenergic and muscarinic receptor autoantibody levels in plasma and cerebrospinal fluid samples between ME/CFS patients and healthy controls.
Post-viral Encephalopathy
This study provides an excellent opportunity to understand the mechanism of long-lasting viral-induced cognitive complications, commonly referred to as “brain fog.”
Kynurenine Trial in ME/CFS
The purpose of the study is to evaluate whether kynurenine is directly connected to ME/CFS patient symptom severity.