Critical Illness, Mechanisms of Recovery, Similarities to ME/CFS
We propose an initial explanation for how ME/CFS could originate and perpetuate by drawing on findings from critical illness and heat stroke research.
Studying CSF to further reveal pathogenesis mechanisms in ME/CFS
The goal of this research is to reveal more information about the role of immunology and neuroinflammation in ME/CFS, and the underlying mechanisms of related pathogenesis that takes place.
Long COVID Clinic Studies
Long COVID Clinic Studies Study AIM The newly established clinic in Uppsala will continue the work of the OMF-Funded MultiCenter Collaborative Study on COVID to ME/CFS progression. LEAD INVESTIGATORS Jonas Bergquist, MD, PhD, Prof, Director ScD Updates and Potential Studies A & B: IRB protocol has been approved, and patients are being recruited. STUDY […]
Home Visit Study
Home Visit Study STUDY AIM This study provides a unique opportunity to bring the lab directly into patient homes and provide immediate analysis of samples over an extended period of time. This longitudinal approach without the invasive and/or PEM-induced measures will be vitally important in other patient cohorts and will decrease the study impact on […]
Deep Proteome and Metabolome Profiling
Deep Proteome and Metabolome Profiling Study AIM Collaborate with OMF CRCs in Uppsala and Melbourne to establish a global perspective. Decode the molecular mechanisms underlying ME/CFS and contributing to specific symptoms with a particular emphasis of post-exertional malaise (PEM) through: Deep phenotyping of ME patients Global proteomic plasma profiling of ME patients Global metabolomics plasma […]
Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS by Jonas Bergquist, MD, PhD, Uppsala Collaboration
From the Desk of Jonas Bergquist, MD, PhD Uppsala University On behalf of my team at the ME/CFS Collaborative Research Centre at Uppsala University, I am pleased to share our paper entitled, “Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie Myalgic Encephalomyelitis/Chronic Fatigue Syndrome” was recently published in Frontiers in Medicine! Thanks in part […]
Neuro Inflammation
Deep Assessment of NeuroinflammationUsing CNS Imaging and Analysis of CSF, Blood, Saliva Samples Study AIM To explore the hypothesis that deranged flow of the cerebrospinal fluid (CSF) due to craniocervical obstructions and/or instability may cause deranged intracranial pressure (ICP), neuroinflammation and cardinal symptoms of ME/CFS. LEAD INVESTIGATORS Jonas Bergquist in collaboration with the Haravard CRC […]
Post-viral Encephalopathy
This study provides an excellent opportunity to understand the mechanism of long-lasting viral-induced cognitive complications, commonly referred to as “brain fog.”