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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada

ME/CFS Collaborative
Research Center

at the CHU Sainte-Justine/
Université de Montréal

Clinical and scientific studies to understand and discover new treatments for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS)

About the research center

The ME / CFS Collaborative Research Center, established in 2020 at CHU Sainte-Justine /Université de Montréal, increases OMF’s international collaborative efforts through the End ME/CFS Project. Directed by Alain Moreau, PhD, the Quebec, Canada-based laboratory has been researching ME / CFS for several years.

Chercheuse en laboratoire regardant le moniteur

Alain Moreau, portrait Alain Moreau, PhD, is a Full Professor in the Department of Stomatology, Faculty of Dentistry and Department of Biochemistry and Molecular Medicine, Faculty of Medicine, at Université de Montréal, Montréal, Québec, Canada. Additionally, Dr. Moreau is the Director of Network for Canadian Oral Health Research. He is the Scientific Director of the Viscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Sainte-Justine University Research Center, Montréal, Québec.

Dr. Moreau’s chief interests of study are pediatric scoliosis, osteoarthritis, osteoporosis, and Myalgic Encephalomyelitis. Dr. Moreau is a member of the Open Medicine Foundation Scientific Advisory Board and is the Director of the Interdisciplinary Canadian Collaborative Myalgic Encephalomyelitis Research Network, a national research network funded by the Canadian Institute of Health Research. 

Core Aims


the pathophysiology of ME/CFS, especially on severely affected persons


the clinical heterogeneity of ME/CFS using provocation studies (stress-test)


a molecular diagnostic test


a multi-omic approach to better stratify patients


molecular profiling of discordant and concordant twins with ME/CFS


multigenerational families affected by ME/CFS


possible treatment plans

Fundamental Philosophy

  • Establish collaborative work with ME / CFS groups to bring different fields of study together
  • Explore novel approaches to test for ME / CFS and treat the disease
  • Develop techniques to stratify ME / CFS patients
  • Predict which treatments will be most successful based on patient’s respective molecular profiling and symptoms
Evguenia Nepotchatykh et Alain Moreau regardent le conseil d'administration

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chercheuse en laboratoire avec des flacons


Multi-Omics Study of ME/CFS (MAESTRO)

The primary goal of this project is to complete our comprehensive analysis of the genome, methylome, miRnome, and their interactions in order to fill the gaps in our understanding of ME/CFS pathophysiology and to identify clinically useful biomarkers.

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Stress-Activated MicroRNAs

Studying microRNAs could help to bridge the conceptual gap between genetic predisposition and environmental factors causing ME/CFS or exacerbating specific symptoms.

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Deep Proteome and Metabolome Profiling

Decode the molecular mechanisms underlying ME/CFS and contributing to specific symptoms with a particular emphasis of post-exertional malaise (PEM). This includes deep phenotyping of ME patients and global proteomic/metabolomics plasma profiling of ME..

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Scientific Team

chercheuse regardant de près des échantillons

CHU Sainte-Justine Research Center
Université de Montréal

Alain Moreau, PhD , Scientific Director

Anita Franco, MSc, Lab coordinator

Dashen Wang, MD, PhD, Research Associate

Mohamed Elbakry, PhD , Research Associate

Viorica Lascau, MSc , Research coordinator – certification manager

Sophie Perreault, RN  , Clinical research nurse

Valerie Tremblay, RN, Clinical research nurse

Hélène Gagnon, RN, Clinical research nurse

Iurie Caraus, PhD , Postdoctoral fellow

Wesam Elremaly, PhD, Postdoctoral fellow

Lynda Chalder, MSc, PhD student

Evguenia Nepotchatykh, BSc, PhD student

Atefeh Moezzi, MSc, PhD student

Corinne Leveau, BSc, MSc student

Bita Rostami, BSc, MSc student

Marie-Yvonne Akoume PhD, Invited professor – ICanCME Research Network Investigator

Valérie Marcil PhD, Associate Professor – ICanCME Research Network Investigator

Emile Levy, MD, PhD ,Full Professor – ICanCME Research Network Investigator

University of Florida Atlantic

Dawei Li, PhD, Associated Professor – ICanCME Research Network Investigator

Jason Kost BSc , Research Assistant – ICanCME Research Network Member

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