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Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation® Canada
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ME/CFS Collaborative Research Center

at Stanford University

Innovative, collaborative, open-data research to end Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS).

About the research center

The ME/CFS Collaborative Research Center (previously known as the CFS Research Center) at Stanford University was established in 2014 and is part of the Stanford Genome Technology Center. Both centers are directed by Ronald W. Davis, PhD, Professor of Biochemistry and of Genetics at Stanford.

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Ron Davis, headshot

Throughout his career, Dr. Davis has conducted cutting edge, innovative, interdisciplinary research and technology development on cancer, immunology, genetics, infectious disease, novel drug development, and nanofabrication of diagnostic instruments.

Dr. Davis was the first to physically map the genome of any organism (1968).

Dr. Davis discovered a simple way to join together DNA from two organisms (“sticky ends”) and was the first to generate a hybrid DNA molecule that could replicate inside of cells (DNA cloning).

Active/ongoing studies

Inactive/Archived Studies

Scientific Team

Director

Ronald W. Davis, PhD, Professor of Biochemistry and Genetics, Stanford University School of Medicine; Director, Stanford Genome Technology Center; Director, Chronic Fatigue Syndrome Research Center at Stanford University; Chair, Open Medicine Foundation ME/CFS Scientific Advisory Board.

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To carry out this ambitious work, Dr. Davis has assembled a team of extraordinary scientists with expertise in a wide variety of areas directly relevant to Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) research.

Collaborative Research Center / Stanford Genome Technology Center

Robert Phair, PhD

Wenzhong Xiao, PhD

Mohsen Nemat-Gorgani, PhD

Peidong Shen, PhD

Laurel Crosby, PhD

Michael Jensen

Fereshteh Jahaniani, PhD

Gozde Durmus, PhD

Julie Wilhelmy

Alex Kashi

Anand Ramasubramanian, PhD

Amit Saha, PhD

Layla Cervantes

Ami Mac, MD

David Kaufman, MD

Bela Chheda, MD

Chris Armstrong, PhD

Katrina Hong

Anna Okumu

Ashley Haugen

Collaborators

Juan Santiago, PhD

Eric Shaqfeh, PhD

Mark M. Davis, PhD

Michael Sikora

Mike Snyder, PhD

Craig Heller, PhD

Lars Steinmetz, PhD

Jonas Bergquist, MD, PhD

Rahim Esfandyarpour, PhD

In Memoriam – Ron Tompkins, MD, ScD

Curt Scharfe, MD

Robert Naviaux, MD, PhD

William Robinson, MD

Lucinda Bateman, MD

Jennifer Frankovich, MD

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Consent management

Consent Preferences

Data Subject Access Request (DSAR) Form 

Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.