BOSS-ME: Biological Outlier and Subtyping Software for ME/CFS

This project will develop a software tool to rapidly look for metabolism anomalies in an individual which might be explained by their genes. It will also look for potentially damaging genes in individuals and it will attempt to group ME/CFS patients based on their genetic and metabolic profiles.
Cellular Nitrogen and Energy Metabolism in ME/CFS

This project aims to test the nitrogen hypothesis, which is that damaging, nitrogen-containing by-products of energy metabolism accumulate more readily in the cells of ME/CFS patients.
Ocular Motor Study
The aim of this project is to fully characterise eye movement changes in ME/CFS on two consecutive days, identifying an ocular motor signature that is unique to the disorder.
SPOT ME: Serial Pediatric Omics Tracking for ME/CFS

This study seeks to understand pathological mechanisms of pediatric ME/CFS (13 to 18 years old), using case-control and longitudinal study design that meshes clinical measures and omics methods.
RAman SPectrometry Based biomarkER discoveRY for Myalgic Encephalomyelitis (RASPBERRY-ME)

The overarching goal of RASPBERRY-ME project is the characterization of the biomolecular signature of Myalgic Encephalomyelitis using Label-free Raman Spectroscopy (RS) and machine learning models.
Precision Medicine for Myalgic Encephalomyelitis Drug Discovery and ClinicaI Trials (REMEDIAL)
The REMEDIAL project continues the work commenced with MAESTRO and will lead to a better understanding of the molecular mechanisms underlying ME/CFS pathophysiology,
the persistence and variability of the symptoms, and will contribute to the identification of targets and therapeutic agents for intervention.
Critical Illness, Mechanisms of Recovery, Similarities to ME/CFS

We propose an initial explanation for how ME/CFS could originate and perpetuate by drawing on findings from critical illness and heat stroke research.
Studying CSF to further reveal pathogenesis mechanisms in ME/CFS

The goal of this research is to reveal more information about the role of immunology and neuroinflammation in ME/CFS, and the underlying mechanisms of related pathogenesis that takes place.
Long COVID Clinic Studies

The clinic in Uppsala continues the work of the OMF-Funded MultiCenter Collaborative Study on COVID to ME/CFS progression.
Home Visit Study
This study provides a unique opportunity to bring the lab directly into patient homes and provide immediate analysis of samples over an extended period of time.
This longitudinal approach without the invasive and/or PEM-induced measures will be vitally important in other patient cohorts and will decrease the study impact on patients from using more invasive and impactful measures (use of 1 peripheral vein catheter for all blood samples, limits the impact on patients).