Announcing OMF's First ME/CFS Clinical Trial!

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Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Long COVID.

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Category: Translations Available

Condensed Precision Medicine Protocol for ME/CFS

The study aims to establish a condensed personalized research protocol that can be used to characterize ME/CFS in individual patients as it pertains to all their unique biological aspects, interacting with a complex chronic disease.

Post-COVID Syndrome to ME/CFS

In 2020, OMF secured a $1 million grant to launch the first year of an international, multi-year study across the five OMF funded Collaborative Research Centers (CRC). The aim of this study is to examine Post-COVID Syndrome transitioning to ME/CFS. We are actively working to raise an additional $2 million for years two and three of the study. I am pleased to share with you an update on the first phase of this groundbreaking — and urgently needed — research project:

Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS by Jonas Bergquist, MD, PhD, Uppsala Collaboration

From the Desk of Jonas Bergquist, MD, PhD Uppsala University On behalf of my team at the ME/CFS Collaborative Research Centre at Uppsala University, I am pleased to share our paper entitled, “Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie Myalgic Encephalomyelitis/Chronic Fatigue Syndrome” was recently published in Frontiers in Medicine! Thanks in part […]

Football Player Jack Emmett Becomes OMF Ambassador!

Football Player Jack Emmett Becomes OMF Ambassador! Open Medicine Foundation Canada(OMFCA) is delighted to kick off the new year with an exciting update: We are proud to welcome professional football player Jack Emmett as OMF’s newest Ambassador!  At 27 years old, Jack Emmett has pursued a career in professional football (soccer) in England.  Having played […]

$4.5M raised in 2020: Your Donations at Work!

Thank you for being a part of the Open Medicine Foundation Canada (OMFCA) family. We are honored by your trust in our efforts to end ME/CFS and related chronic, complex diseases.  The following accomplishments from 2020 are possible because of you, your support of our work, and your dedication to our shared vision of a world […]

Insights from Invasive Cardiopulmonary Exercise Testing by David Systrom, MD, Harvard Collaboration

Dr. David Systrom, pulmonary physician at Brigham & Women’s Hospital and investigator at Massachusetts General Hospital in association with the Harvard ME / CFS Collaboration, has recently published, “Insights from Invasive Cardiopulmonary Exercise Testing of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome,” in CHEST Journal. This research is proudly funded in part by Open Medicine Foundation (OMF). The […]

20 reasons to give the gift of hope this year!

Last chance to donate in 2020! As we come to the end of 2020, Open Medicine Foundation Canada (OMFCA) wishes you and yours a peaceful New Year’s. Thanks to the generosity of our community, we remain hopeful for a promising 2021. It’s not too late to join our community of supporters and make your 2020 […]

Run Across Ontario | An OMFCA Supporter’s Journey to Raise Awareness

Today we are honored to share the incredible story of Open Medicine Foundation Canada (OMFCA) supporter Terry from Canada, who has embarked on a challenging journey to raise both money and awareness for ME/CFS research. ME/CFS is a complex disease with a varying spectrum of severity. Some are bedbound indefinitely, while others, like Terry, have […]

Meet Artist & ME/CFS Advocate Christina Baltais | #TripleGivingTuesday

#TripleGivingTuesday Community Spotlight An Interview with Artist & ME/CFS Advocate, Christina Baltais As part of Triple Giving Tuesday, Open Medicine Foundation Canada (OMFCA) is honored to share our Community Spotlight on artist and ME/CFS advocate Christina Baltais. Christina’s profoundly compassionate and moving artwork uses diverse mediums, including painting, collage, photography, writing, and art videos. A […]

A Message from OMFCA Leadership

A Message from OMF Leadership Open Medicine Foundation Canada (OMFCA)’s Triple Giving Tuesday campaign is almost a week in! We want to take a moment to share a message from OMF leadership. Watch the video now: “ME/CFS takes an incredibly vital human and just puts them in a box that people don’t even know they are living […]

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Microvesicles and viral sequencing
Microvesicles are a type of extracellular vesicle that is released from the cell membrane. Vesicles are small, fluid-filled sacs or vacuoles within the body. Sequencing is a technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA (or viral) molecule.
NMR Metabolomics
NMR (Nuclear Magnetic Resonance) is an instrument/tool used to perform metabolic studies, metabolic profiling, and metabolomics in biofluids and tissues for more than 40 years using magnetic fields. There is a very close connection between metabolic measurements and NMR. This connection has flourished because of NMR’s many unique strengths for characterizing complex mixtures’ chemical composition.
Proteomics
The large-scale study of proteins, which are large, complex molecules that are required for structure, function, and regulation of the human body's tissues and organs.
Leukocyte Genomics
A leukocyte is a colorless cell circulating in the blood and body fluids and is involved in counteracting foreign substances and disease. A genome is all genetic material of an organism. Genomics is a biology field focusing on the structure, function, evolution, mapping, and editing of genomes. Therefore, leukocyte genomics is the study of all genetic material of leukocytes.
Metabolomics
Metabolomics is a way to study metabolism – that is, through measuring amounts of the metabolites (small molecules) produced by our bodies as we convert food into energy and other molecules that our cells need to survive. Metabolomics technology is ‘large-scale,’ meaning that several thousand metabolites can be measured from a single sample of e.g., blood or urine.
Micro RNA
Cells use Micro RNA to control whether a particular gene is making too much, too little or the normal amount of its protein at a particular time.
Autoantibodies
Antibodies that react with self-molecules and that occur in healthy individuals and are referred to as natural antibodies or autoantibodies.
Extracellular DNA for viral reactivation and Mitochondrial DNA
exDNA (extracellular DNA), exDNA is often secreted actively and is used to perform several tasks, thereby offering an attractive target or tool for biotechnological, medical, environmental, and general microbiological applications. Viruses are intracellular parasites that rely to a significant extent on the host cell for replication. Viral reactivation occurs when an active replication of the viral genome results in a lytic (degradation of the cell) infection characterized by the release of new progeny (descendant) virus particles.
Immune cell profiling
The immune system has many important regulatory roles in disease development and progression. Given the emergence of effective immune therapies, reliable predictors of response are needed. Immune cell profiling determines response by evaluating immune cell populations from treated and untreated samples. For our purposes, we will evaluate the white blood cell response to the viral infection using a process called “Cytof.”